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Pyrrole Disorder

Pyrroles :

At The Compounding Lab we compound many preparations that support and assist in creating wellness .The Compounding Lab pharmacists have advanced education in compounding for the special nutritional and pharmaceutical needs of patients with the Autism Spectrum Disorders, including autism, allergies, asthma, & attention deficit hyperactivity disorder (ADHD). We compound custom formulations to avoid gluten, casein, preservatives, corn , dyes, and artificial flavours. We specialise in making medications tasty and patient-friendly, which can be challenging in these patients, so we pride ourselves in working with parents and physicians to “think outside the box” and find unique solutions for unique needs. Suspension and transdermal delivery methods to overcome the impossible challenge with oral therapy.
We stock several lines of high-quality nutraceuticals designed specifically for these patients, including many potent probiotics. The Compounding Lab goal is to work with you and your child’s doctor or consultant to customise a regimen that meets your child’s specific needs, improving the quality of life for both child and parent. Pyrrole disorder is becoming more and more prevalent both in children with ADHD and autism and in the general population. It is a little known condition even though its discovery dates back to research into schizophrenia in the 1960s where it was first given the name ‘mauve factor’.
Pyrrole disorder (also known as pyrroluria) is thought to be a genetic disorder of haemoglobin metabolism that produces too much of a molecule called kryptopyrrole which is excreted in the urine. The kryptopyrrole molecule itself is harmless; however it binds with vitamin B6 and zinc, excreting them from the body along with the kryptopyrrole molecule, creating a double deficiency of zinc and B6, the hallmark of pyrrole disorder. There are also changes to fatty acid metabolism which lead to high levels of an omega 6 fatty acid call arachidonic acid. Pyrrole disorder is detected through a urine test costing approximately $100.00 from safe laboratories order test kit online now.

Treatment involves supplementing zinc and B6, both active B6 and standard vitamin B6 are needed. Other minerals such as manganese may also be required along with evening primrose oil.

Vitamin B6 is critical for the production of neurotransmitters and deficiencies can have a profound effect on both mental and physical health. The symptoms are thought to be from the deficiency of B6 and zinc that pyrrole disorder creates. Pyrrole disorder can be triggered by a traumatic event and high stress levels and is often part of the picture for ADHD, Autism, Aspergers, PDD, ODD, Tics, Tourette’s syndrome, depression, schizophrenia and bipolar disorder.

Is Pyrrole Disorder Unique to Autism?

We see more and more children who are testing positive to pyrrole disorder, both on the spectrum and in the general population. Pyrrole disorder is not a condition specific to Autism nor does it cause Autism. It is thought that pyrrole disorder contributes to the retention of toxins and heavy metals seen in autistic children.
There are many markers of pyrrole disorder and we do notice a definite genetic pattern. Many times if a child is positive then one of the parents will also test positive and notice a significant improvement in symptoms when taking the supplements.

How do I Know if my Child has Pyrrole Disorder?

Below I have listed some common symptoms associated with pyrrole disorder in children.
  • Sleep problems, particularly taking a long time to fall asleep and waking up easily at night.
  • Sensitivity to the labels on clothes, sensitivity to specific fabrics – eg ‘feels prickly’.
  • Anxiety. (Anxiety can contribute to digestive upsets such as IBS.)
  • Poor tolerance of stress.
  • Depression.Pessimistic outlook.Mood swings, emotional lability .
  • Anger and violence out of proportion to the situation, including rage.
  • Sensory issues.
  • Poor functioning of the digestive system, including poor absorption of nutrients as well as food sensitivities
  • Low immunity – constantly suffering with coughs and colds. Motion sickness. Reading and learning problems.
  • Poor memory.
  • Slow growth. Delayed puberty.
  • Unpleasant body odour.
  • Stretch marks on skin.
  • Pain in joints and extremities.
  • Sweet fruity breath and body odour, Problems with sugar metabolism, Allergies

A simple urine test can establish the presence of pyrroles in someones urine. Once established and determined if the person is a under or overmethylator you can treat with effective nutraceutical supplementation specifically compounded for you.

There is often a family history of these factors as well as a history of addictions such as alcoholism, drugs and gambling as well as more severe symptoms such as severe depression and anxiety, schizophrenia, suicide, criminality, seizures and physical debilitation.
Further Information on Pyrrole Disorder
Read information compiled by Bill Walsh, Head Scientist at the Pfeiffer Institute or email our Pharmacists.


What is Pyroluria? It is a genetically acquired chemical imbalance in which the body produces an abnormally large number of pyrroles. A pyrolle is a chemical consisting of a 5 membered aromatic ring. These chemicals are the byproduct of hemoglobin synthesis and have no known function in the body; they are normally excreted in the urine. Most people have very few pyrroles in their system at any given time; certain individuals, however, have an unusually high number of pyrroles in their bodies, resulting in a condition known as pyroluria.


Also known as Mauve Factor (due to the mauve color visible on testing paper during urinalysis) or pyrrole disorder, pyroluria occurs when the pyrroles bind to pyroxidine (vitamin B6) and zinc, causing these vital nutrients to be excreted from the body in large amounts.

Deficiencies of B6 and zinc are associated with a wide range of emotional and psychiatric problems. Nervousness, extreme irritability, anxiety, depression, short-term memory problems, and explosive anger have all been linked to pyroluria. A large percentage of patients with psychiatric disorders such as schizophrenia exhibit high levels of pyroles; emotionally disturbed children and excessive alcohol intake also tend to have an abnormally high pyrrole count.

In addition, zinc deficiencies have been associated with a number of physiological disorders, including poor immune function, poor growth, and delayed sexual development. Because zinc and B6 are so important to both our overall physical and mental health, identifying and treating this devastating condition is critical.


Clinical Use and Diagnosis: Pyrrole disorder is seen by an elevated urine kryptopyrrole, which results in a dramatic deficiency of zinc and vitamin B6. Pyroluria, Elevated Pyrroles, or a high Kryptopyrrole result, is frequently identified in behavior disorders, autism, Asperger’s, ADHD, ADD, depression, bipolar disorders, assaultive/aggressive/violent behavior, schizophrenia and other mental and emotional conditions. Pyroluria, elevated pyrroles, or a high kryptopyrrole result, can create poor tolerance of physical and emotional stress, poor anger control, emotional mood swings, depression, anxiety, poor short term memory, frequent infections, inability to tan, poor recall for dream abnormal fat distribution, sensitivity to light and sound and tactile sensitivities. These symptoms can be treated.

Testing: The presence of urinary pyrroles can be established using a colorimetric biochemical screening test adapted from Carl Pfeiffer’s method. Urine is collected in two vials, one containing ascorbic acid, wrapped in aluminum foil then frozen immediately for transport. The analysis is very sensitive and results are expressed as µg/dL (micro grams of urinary pyrrole per deciliter of urine). Samples containing urinary pyrroles at a level of 0 - 10 µg/dL are considered normal or negative, samples of 10 – 15 µg/dL are considered borderline, and samples above 15 µg/dL are considered positive.

Treatment: Treatment of pyroluria consists of a replacement of zinc and vitamin B6. Because the treatment is replacing deficiencies not pharmacologic, it needs to be titrated to individual requirements. A variety of factors are taken into consideration when developing a treatment regimen. Both zinc and B6 supplementation need to be directed by a practitioner as to much can be toxic, use of wrong form ineffective, and avoiding competing minerals and supplements may be necessary.


The Compounding Lab can work with your practitioner to create a precise Formula with B group Vitamins & Zinc that is taken each morning & Night. Supplementation is long term so finding an ideal method for you or your child is critical for compliance. In addition Omega 6 is important and we can find a suitable supplement .