The Methylation Cycle is a very complex biochemical pathway that manage a wide range of bodily functions. The functions that are commonly seen affected are Detoxification, Maintaining Immune function , Maintaining Cellular energy, Improving mood balance – improving serotonin and Controlling inflammation.

Symptoms often seen when the Methylation process isnt working well are fatigue, depression, obsessive and compulsive and addictive type personalities, good tolerance of cold, poor tolerance of heat, unexplained nausea, poor pain tolerance, excess/abundant saliva in mouth, hyperactivity, frequent colds/flu, phobias, highly motivated and hard-driving personality, good creativity/imagination, high libido, joint pain/swelling/stiffness, excess perspiration and warm skin.

To test for methylation we measure histamine and look for high homocysteine levels as they also indicate undermethylation. It is common for suffers to also have low copper levels as copper is part of the enzyme histaminase which is involved in the metabolism of histamine. Copper should also be tested by serum ceruloplasmin.

MTHFR gene mutations may also effect methylation rates . A MTHFR gene blood test is available to see if you have hetrozygous or homozygous gene expressions.

Treatment options are tailored to the type of methylation status. Firstly as a patine you need to run several blood tests and do a pyrrole urine test to see the extent of the Methylation, then treatment involves a combination of nutrients. These include methylcobalamin (methyl-B12), methylfolate (5-MTHF)and pyridoxyl-5-phosphate (P5P), Zinc, Vitamin C, Magnesium and B6. A methyl donor such as Methionione, Trimethylglycine or SAMe can also be used in an undermethylator .

Undermethylation can induce depression suffers and in these patients should avoid folic acid as it can further reduce serotonin levels even though it can assist with methylation. Manganese, copper, DMAE and choline may also worsen depression symptoms and thus should also be avoided in depressive cases. If undermethylators cooperate with treatment and works to give up detrimental addictions, the prognosis is good with improvement usually noted in 4-8 weeks with about 3-6 months needed to correct this chemical imbalance.

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