At the Compounding Lab we prepare all types of Progesterone in hundreds of different strengths. From 0.01% through to 10% Cream, Troche or Capsule.
Progesterones best-known role is in maintaining a healthy pregnancy. When a woman ovulates, the follicle that has burst to release the ovum becomes the corpus luteum. The corpus luteum secretes anywhere from 4 mg to 28
mg of progesterone per day during the two weeks between ovulation and menstruation, with the average being 22 mg to 25 mg. If pregnancy takes place, the corpus luteum continues to make progesterone throughout the
first trimester, playing an indispensable role in maintaining the pregnancy until the placenta can take over the job of providing progesterone. By the third trimester of pregnancy, the placenta is making up to 400 mg a day of this pro- gestational hormone. -
Women who are in or past menopause can benefit from natural progesterone supplementation. Natural progesterone stimulates the formation of new bone and may help to prevent breast cancer. It counteracts the blood clotting effects of estrogens, improves vascular tone (the ability of blood vessels to stretch and contract in response to the body’s requirements), and is believed to protect against the build up of atherosclerotic plaques and coronary artery spasms that lead to heart attack.
It’s a gentle mood enhancer and helps to maintain normal libido. Low thyroid activity is a common problem for postmenopausal women. Oestrogen inhibits thyroid hormone activity.
Balancing excess estrogens with progesterone enables the body tobetter utilize thyroid hormone, and can help women to wean themselves off of thyroid hormone replacement drugs.
Progesterone builds bones. One of the main arguments in favour of HRT is that it has been shown in multiple studies to preserve bone mass and protect against osteoporotic fractures. The truth is that while estrogens – even the horse- derived estrogens that comprise Premarin – do preserve bone mass, the overall risks of HRT have been found to outweighany beneficial effects it might have on bone health. The synthetic progestin medroxyprogesterone has been found to increase bone density when given to young women who are not menstruating or ovulating.20 The work of John Lee, M.D., and other like-minded clinicians has shown that natural progesterone has the same bone-building effect in both pre- and postmenopausal women, without the side effects that often occur with the synthetic progestins. Oestrogen maintains bone mass by subduing the activity of osteoclasts – specialized bone cells that break down old bone to make room for new. Progesterone builds bone by stimulating the activity of osteoblasts, bone cells that pull calcium, magnesium and phosphorus from the blood so that it can be incorporated into the bones. Progesterone and breast cancer Progesterone modulates much more than the course of a pregnancy. It interacts with oestrogen in dozens of ways; the best detailed explanation of these effects can be found in Dr. Lee’s writings. The short story on progesterones relationship with cancer is that while oestrogen encourages cellular growth (which is why it is carcinogenic in excess), progesterone encourages cells to differentiate, or mature. Immature cells are more likely to turn into cancerous cells.
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